Olympic 100m champion Eileen Thompson-Herrah proved to be the Diamond League winner over a host of competitors including Britain’s Dina Asher-Smith in Eugene.
The Jamaican ran 50 meters and won with a time of 10.79 metres.
Asher-Smith got off to the steepest start but was overtaken to finish fourth with a season better than 10.98sec.
Elsewhere, Kelly Hodgkinson won the 800m while compatriot Matt Hudson Smith set a new world record in the 400m.
Hodgkinson continued her impressive start to the season as she climbed to the 800m victory in a world best time of 1 minute 57.72 seconds.
American Athing Mu, who beat Hodgkinson for the Olympic gold medal last summer, withdrew from the event earlier in the week, dismissing the crowd from comparing the event’s two superstars.
Hodgkinson’s compatriot Gemma Rickey finished eighth.
US-based Hudson-Smith took some relief after an apparent false start to smash 25-year-old Britain’s Ewan Thomas’ 400m record.
Hudson Smith’s time of 44.35 seconds in third is a hundredth of a second improvement over Thomas’s mark in 1997.
Thompson-Herah puts on markers
Asher Smith’s time was an improvement from her second 11.11 win in Birmingham last weekend
However, she and the rest left behind the fateful winner’s announcement of their intentions for this season.
Thompson-Herrah, who defended the 100m and 200m in the Olympic doubles race in Tokyo last summer, has been hampered by Achilles and shoulder injuries this season, but he moved through gears brilliantly to push through the second half of the race.
American Sha Carrie Richardson, who missed Tokyo after testing positive for cannabis, He finished second with a time of 10.92 seconds, directly ahead of Jamaica’s Sherika Jackson.
Her victory on the track came as she ran 10.54 last year – the second fastest time in history – which hosted the World Championships in July.
“You’ve got me ready for the championship title in Jamaica next month,” said Hera Thompson. “I am happy to see where I am. The result is good.”
Shelley-Ann Fraser-Price, the 100m silver medalist behind Thompson Hirah in Tokyo, won the 200m with a time of 22.41.
Fraser-Price has already made sure of her 100m at the World Championships – she automatically qualifies for the defending Doha tournament in 2019.
She has indicated that she will wait until after next month’s competitions in Jamaica to decide whether to try to double the championship by running the 200m as well.
Olympic champion Laura Muir found Faith Kipigon very strong in the 1500m. He led the Kenyan to victory in an impressive three minutes and 52.59 seconds while Muir slipped back to eleventh place.
Norway’s Jakob Ingbrigtsen took the victory in three minutes 49.76 seconds while Trayvon Brommel beat fellow Americans Fred Kerley, Christian Coleman and Noah Lyles to win the 100 meters in 9.93 seconds.